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大鼠子宫和胃条中5-羟色胺受体的异质性。

Heterogeneity of 5-hydroxytryptamine receptors in the rat uterus and stomach strip.

作者信息

Wrigglesworth S J

出版信息

Br J Pharmacol. 1983 Dec;80(4):691-7. doi: 10.1111/j.1476-5381.1983.tb10059.x.

DOI:10.1111/j.1476-5381.1983.tb10059.x
PMID:6571226
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2045060/
Abstract

Experiments were performed using the rat isolated uterus and the rat stomach strip to investigate the effects of 5-hydroxytryptamine (5-HT) on 5-HT receptors in the presence of different antagonists. Amitriptyline, methysergide and trazodone were used to antagonize the response to 5-HT in these tissues. The pA2 value for amitriptyline with 5-HT as the agonist was estimated from the Schild plot analysis and found to differ significantly (P less than 0.05) in the stomach strip (6.36) from that in the isolated uterus (9.06). A similar difference was found using trazodone; here the pA2 value was 6.74 in the stomach strip and 8.49 in the isolated uterus. These results indicate a difference between the two tissues. This difference is discussed in terms of heterogeneity of 5-HT receptors.

摘要

利用大鼠离体子宫和大鼠胃条进行实验，以研究在存在不同拮抗剂的情况下5-羟色胺（5-HT）对5-HT受体的影响。使用阿米替林、甲基麦角新碱和曲唑酮来拮抗这些组织对5-HT的反应。通过Schild图分析估计以5-HT为激动剂时阿米替林的pA2值，发现其在胃条（6.36）中与在离体子宫（9.06）中存在显著差异（P小于0.05）。使用曲唑酮时也发现了类似差异；此处胃条中的pA2值为6.74，离体子宫中的为8.49。这些结果表明两种组织之间存在差异。根据5-HT受体的异质性对这一差异进行了讨论。

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本文引用的文献

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Relative activity of some inhibitors of mono-amine oxidase in potentiating the action of tryptamine in vitro and in vivo.一些单胺氧化酶抑制剂在体外和体内增强色胺作用方面的相对活性。
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