Badran A F, Moreno F R, Echave Llanos J M
Rev Esp Oncol. 1984;31(4):591-600.
The hepatocyte mitotic index curve in hepatectomized hepatoma-bearing mice, rises earlier, has a greater amplitude and is less synchronized than that of normal hepatectomized mice. This indicates a stimulation (more mitosis in a shorter time period) produced by the presence of the tumors. The sinusoid litoral cells mitotic index curve in hepatectomized hepatoma-bearing mice appears earlier and is much less synchronized than that of normal hepatectomized mice. Nevertheless both curves have the same amplitude for the whole sampling period and the early stimulation is quickly compensated by lower values (apparent inhibition) appearing in the resting (light) period.
肝癌荷瘤小鼠肝切除后的肝细胞有丝分裂指数曲线比正常肝切除小鼠的曲线上升更早、幅度更大且同步性更低。这表明肿瘤的存在产生了一种刺激（在更短的时间段内有更多的有丝分裂）。肝癌荷瘤小鼠肝切除后的肝血窦边缘细胞有丝分裂指数曲线比正常肝切除小鼠的曲线出现得更早且同步性更低。然而，在整个采样期间，两条曲线的幅度相同，早期刺激会被静止（轻）期出现的较低值（明显抑制）迅速补偿。
