Vasil'ev S V
Biull Eksp Biol Med. 1979 Nov;88(11):595-6.
The action of melatonin on mitosis of the mouse ascites Gelstein 22A hepatoma has been studied in C3HA male mice with 7-day ascites. The cells of ascites hepatoma have shown the metaphase block after intraperitoneal injection of melatonin. It was found that 3 hours after administration melationin at a concentration of 200 and 100 micrograms per 1 g body weight induces an increase in the mitotic index and accumulation of mitoses at the stage of metaphase.
已在患有7日龄腹水的C3HA雄性小鼠中研究了褪黑素对小鼠腹水吉尔施泰因22A肝癌细胞有丝分裂的作用。腹腔注射褪黑素后，腹水肝癌细胞出现中期阻滞。结果发现，以每1克体重200微克和100微克的浓度给药褪黑素3小时后，有丝分裂指数增加，且在中期阶段有丝分裂积累。
