Vengerovskiĭ A I, Sedykh I M, Saratikov A S
Biull Eksp Biol Med. 1987 Aug;104(8):192-5.
The administration of an antiepileptic drug--benzobamilum-to rats with CCl4-induced hepatitis prevents the development of liver parenchyma necrosis, promotes the retention of normal enzyme activity in hepatocytes, stimulates the excretory and antitoxic liver functions. The drug has antioxidant properties, inhibits the production of lysophosphatidylcholine and the reduction in phosphatidylcholine content in the liver homogenates but fails to intensify CCl4-induced steatosis.
给四氯化碳诱导的肝炎大鼠施用抗癫痫药物——苯巴比妥,可防止肝实质坏死的发展,促进肝细胞中正常酶活性的保留,刺激肝脏的排泄和解毒功能。该药物具有抗氧化特性,可抑制肝匀浆中溶血磷脂酰胆碱的产生和磷脂酰胆碱含量的降低,但不能加剧四氯化碳诱导的脂肪变性。