Weinstein Y, Isakov Y
Immunopharmacology. 1983 Feb;5(3):239-50. doi: 10.1016/0162-3109(83)90030-9.
Effects of metabolites of testosterone and of anabolic androgens on bone marrow and thymus of ovariectomized mice were studied. Steroids contained in capsules made of silastic tubing were implanted on the day of castration or were injected at the day of castration (Noralone and T.P.), lymphatic organs were examined two weeks later. It was found that testosterone, 5 alpha-DHT, 3 alpha-diol, Dianabole, T.P., and Noralone caused increases in the relative number of large cells and in activity of 20 alpha SDH in bone marrow. Concomitantly, these steroids caused a marked reduction in thymus cell number and an increase in the responsiveness of the thymus cells to Con A and PHA. The steroid 3 beta-diol increased marrow cell 20 alpha SDH activity but did not affect the thymus cell number. Other steroids tested, Ad-dione 3 alpha or 3 beta-androsterone, 5 beta-DHT, epitestosterone, and progesterone had no effect on thymus or bone marrow.
研究了睾酮代谢产物以及合成代谢雄激素对去卵巢小鼠骨髓和胸腺的影响。在去势当天，将含于硅橡胶管制成的胶囊中的类固醇植入，或在去势当天注射（诺龙和丙酸睾酮），两周后检查淋巴器官。结果发现，睾酮、5α -双氢睾酮、3α -二醇、大力补、丙酸睾酮和诺龙可使骨髓中大细胞的相对数量增加，并使20α -羟甾脱氢酶（20α SDH）的活性增强。同时，这些类固醇可使胸腺细胞数量显著减少，并使胸腺细胞对刀豆球蛋白A（Con A）和植物血凝素（PHA）的反应性增强。类固醇3β -二醇可增加骨髓细胞20α SDH的活性，但不影响胸腺细胞数量。所测试的其他类固醇，雄二酮3α或3β -雄甾酮、5β -双氢睾酮、表睾酮和孕酮对胸腺或骨髓均无影响。
