Slootweg P J, Müller H
J Maxillofac Surg. 1983 Feb;11(1):13-9. doi: 10.1016/s0301-0503(83)80006-x.
27 patients with verrucous lesions of the oral mucosa were studied with reference to the validity of a separation of the entity verrucous hyperplasia from verrucous carcinoma, based on an exophytic or an endophytic growth pattern of the hyperplastic epithelium. The occurrence of other mucosal lesions in these patients was also recorded. It is concluded that verrucous hyperplasia probably represents a morphological variant of verrucous carcinoma. In 37% of the patients, squamous cell carcinoma was found as a coexisting or separately occurring disease and in 26% epithelial dysplasia was also present. It is postulated that the existence of a verrucous carcinoma must be considered to be an expression of an ubiquitous premalignant change in the whole oral mucous membrane. Finally, some notes are made on the entities florid oral papillomatosis and chronic hyperplastic candidosis in relation to oral verrucous carcinoma.
对27例口腔黏膜疣状病变患者进行了研究，旨在根据增生上皮的外生性或内生性生长模式，探讨从疣状癌中区分出疣状增生这一实体的有效性。同时记录了这些患者中其他黏膜病变的发生情况。得出的结论是，疣状增生可能是疣状癌的一种形态学变体。在37%的患者中，发现鳞状细胞癌为并存或单独发生的疾病，26%的患者还存在上皮发育异常。据推测，疣状癌的存在必须被视为整个口腔黏膜普遍存在的癌前病变的一种表现。最后，就口腔疣状癌相关的口腔乳头状瘤病和慢性增生性念珠菌病这两个实体作了一些说明。
