Meltzer H Y, Arora R C, Tricou B J, Fang V S
Psychiatry Res. 1983 Jan;8(1):41-7. doi: 10.1016/0165-1781(83)90137-3.
Two putative biological markers of some forms of depressive illness, the dexamethasone suppression test (DST) and the Vmax of serotonin (5-hydroxytryptamine, 5-HT) uptake in blood platelets, were studied in 40 unipolar, bipolar, and schizoaffective depressed patients. The Vmax levels in those whose cortisol levels suppressed normally after dexamethasone (n = 25) were not significantly different from those of the nonsuppressors (n = 15). When a criterion of Vmax greater than or equal to 8.5 pmoles/10(7) platelets/minute of 14C-5-HT uptake was used as the lower limit of normal, 18 patients had Vmax values lower than normal, only four of whom were nonsuppressors. There was a tendency for the incidence of lower than normal Vmax levels in nonsuppressors (4/15, 26.7%) to be less than that of the suppressors (14/25, 56.0%). These results suggest that the two abnormalities are independent of each other but tend to support the hypothesis that decreased Vmax may be an adaptive response which restores serotonergic function to normal. Twenty-nine of the 40 patients (72.5%) had one or both abnormalities, a finding which suggests that determination of both parameters would significantly increase the proportion of depressed patients who could be diagnosed by these biological tests.
在40名单相、双相和分裂情感性抑郁症患者中，对某些形式的抑郁症的两种假定生物标志物——地塞米松抑制试验（DST）和血小板中血清素（5-羟色胺，5-HT）摄取的最大速度（Vmax）进行了研究。地塞米松后皮质醇水平正常抑制的患者（n = 25）的Vmax水平与未抑制者（n = 15）的Vmax水平无显著差异。当将14C-5-HT摄取的Vmax大于或等于8.5皮摩尔/10(7)个血小板/分钟作为正常下限标准时，18名患者的Vmax值低于正常，其中只有4名是未抑制者。未抑制者中Vmax水平低于正常的发生率（4/15，26.7%）有低于抑制者（14/25，56.0%）的趋势。这些结果表明，这两种异常相互独立，但倾向于支持以下假设：Vmax降低可能是一种适应性反应，可使血清素能功能恢复正常。40名患者中有29名（72.5%）有一项或两项异常，这一发现表明，测定这两个参数将显著增加可通过这些生物学检测诊断的抑郁症患者的比例。
