Arora R C, Kregel L, Meltzer H Y
Biol Psychiatry. 1984 Jun;19(6):795-804.
Serotonin (5-HT) uptake in blood platelets from depressed patients and normal controls were studied over a 2-year period to determine if seasonal variations were present. Vmax, a measure of the number of 5-HT uptake sites in normal controls and depressed patients, was significantly higher in fall and winter than in spring and summer; Vmax in the depressed patients was lower than in normal controls throughout the year. Normal controls showed lower Vmax in April and June. A similar trend was present in the depressed patients but the lowest values were found in the month of December. The necessity of considering seasonal variations in this and other putative biological markers is emphasized.
在两年时间里，对抑郁症患者和正常对照者血小板中的血清素（5-羟色胺，5-HT）摄取情况进行了研究，以确定是否存在季节性变化。Vmax是衡量正常对照者和抑郁症患者中5-HT摄取位点数量的指标，在秋季和冬季显著高于春季和夏季；抑郁症患者的Vmax全年均低于正常对照者。正常对照者在4月和6月的Vmax较低。抑郁症患者也呈现出类似趋势，但最低值出现在12月。强调了在这一及其他假定生物标志物中考虑季节性变化的必要性。
