标记基因座与同胞定量性状之间的连锁关系。
Linkage between a marker locus and a quantitative trait of sibs.
作者信息
Cockerham C C, Weir B S
出版信息
Am J Hum Genet. 1983 Mar;35(2):263-73.
Abstract
Several variations of a method for detecting linkage between a marker locus and a quantitative trait in full sib families are presented along with computational details. All variations are based on contrasts within qualifying families of three or more sibs. The empirical powers of the various test statistics, evaluated by simulation, were very similar, and also similar to that of Smith. These single-generation tests are likely to be successful only for many families and relatively tight linkage.
摘要
本文介绍了全同胞家系中标记基因座与数量性状之间连锁关系检测方法的几种变体，并给出了计算细节。所有变体均基于三个或更多同胞的合格家系内的对比。通过模拟评估的各种检验统计量的经验功效非常相似，且与史密斯的方法的功效也相似。这些单代检验可能仅在有许多家系且连锁相对紧密的情况下才会成功。
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本文引用的文献
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