谷胱甘肽对用二甲基亚砜、丁酸或12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯处理的HL - 60细胞的影响。
The effect of glutathione on HL-60 treated with dimethylsulfoxide, butyric acid or 12-O-tetradecanoylphorbol-13-acetate.
作者信息
Zucker R M, Whittington K B, Decal D L
出版信息
FEBS Lett. 1983 May 2;155(1):107-12. doi: 10.1016/0014-5793(83)80219-1.
HL-60 promyelocytic leukemic cells can be induced to differentiate into granulocytes or macrophages. Reduced glutathione lyses undifferentiated HL-60 cells but has minimal effect on their differentiated counterparts. The addition of reduced glutathione to HL-60 promyelocytic leukemic cells retards cell growth and lyses cells. HL-60 cells can be induced to differentiate into granulocytes with dimethylsulfoxide butyric acid or into macrophages with 12-O-tetradecanoylphorbol-13-acetate. After treatment of HL-60 cells with these inducing agents the HL-60 cells become unresponsive to the effects of glutathione.
HL-60早幼粒细胞白血病细胞可被诱导分化为粒细胞或巨噬细胞。还原型谷胱甘肽可裂解未分化的HL-60细胞，但对其分化后的对应细胞影响极小。向HL-60早幼粒细胞白血病细胞中添加还原型谷胱甘肽会阻碍细胞生长并裂解细胞。HL-60细胞可用二甲基亚砜丁酸诱导分化为粒细胞，或用12-O-十四烷酰佛波醇-13-乙酸酯诱导分化为巨噬细胞。用这些诱导剂处理HL-60细胞后，HL-60细胞对谷胱甘肽的作用不再有反应。
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