Glaze D G, Frost J D, Jankovic J
Neurology. 1983 May;33(5):586-92. doi: 10.1212/wnl.33.5.586.
Overnight polygraphic sleep studies, which included accelerometry and video monitoring, were performed on 14 Tourette patients before therapy and on 11 age-matched controls. Tourette patients less than 23 years old had a significantly increased percentage of stage 3/4 sleep, had an increased number of awakenings, had a decreased percentage of REM sleep, experienced paroxysmal events during stage 4 sleep, and had motor tics during all stages of sleep. Three patients were treated with tetrabenazine and subsequently showed significant decreases in percentage of total sleep, number of awakenings, and number of tics during sleep. These findings suggest a disorder of arousal in Tourette patients.
对14名图雷特氏症患者在治疗前以及11名年龄匹配的对照者进行了夜间多导睡眠监测研究，其中包括加速度计和视频监测。年龄小于23岁的图雷特氏症患者3/4期睡眠的百分比显著增加，觉醒次数增多，快速眼动睡眠百分比降低，在4期睡眠期间出现阵发性事件，并且在睡眠的各个阶段都有运动性抽搐。三名患者接受了丁苯那嗪治疗，随后总睡眠百分比、觉醒次数和睡眠期间抽搐次数均显著下降。这些发现表明图雷特氏症患者存在觉醒障碍。
