Romano M, Cecco L, Cerra M, Montuori R, De Rosa C
Tumori. 1980 Dec 31;66(6):677-87. doi: 10.1177/030089168006600602.
Urinary polyamine levels were determined in patients with acute leukemia, before and during chemotherapy, in order to confirm whether tumor cell death, due to successful chemotherapy, increases the release in urine and serum of polyamines from tumor tissues (12). Comparison between the polyamine test and cytological data indicated that a rise in urinary spermidine levels occurs during the first 3 days of therapy, both in the responsive and unresponsive patients. However, in the responsive patients the spermidine increase was higher (at 5% significant level) than in the unresponsive ones, and it was coincident with the fall of the blast cells and the revival of normal hematopoiesis. Increases in putrescine levels were also observed, but there were no significant differences (5% level) between the 2 groups of patients. When polyamine determinations were carried out following chemotherapy cycles, the relapse of the disease was always accompanied by an increase in putrescine.
为了确定成功化疗导致的肿瘤细胞死亡是否会增加肿瘤组织中多胺向尿液和血清中的释放，对急性白血病患者在化疗前及化疗期间的尿多胺水平进行了测定(12)。多胺检测结果与细胞学数据的比较表明，在治疗的前3天，无论患者对治疗有无反应，尿亚精胺水平都会升高。然而，有反应的患者亚精胺的升高幅度（在5%显著水平）高于无反应的患者，且与原始细胞数量的下降及正常造血功能的恢复同时出现。腐胺水平也有升高，但两组患者之间无显著差异（5%水平）。在化疗周期后进行多胺测定时，疾病复发总是伴随着腐胺的增加。
