氧氟沙星（DL-8280）的抗支原体活性。
Antimycoplasmal activity of ofloxacin (DL-8280).
作者信息
Osada Y, Ogawa H
出版信息
Antimicrob Agents Chemother. 1983 Mar;23(3):509-11. doi: 10.1128/AAC.23.3.509.
Abstract
Ofloxacin (DL-8280; (+/-)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1- pipera-zinyl)-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid) showed a broader spectrum and a greater potency of antimycoplasmal activity than did pipemidic acid, norfloxacin, tetracyclines, and lincomycin, but was inferior to erythromycin. Its mycoplasmacidal potency against clinical isolates of Mycoplasma pneumoniae was also greater than that of other quinolones and tetracyclines.
摘要
氧氟沙星（DL - 8280；（±）-9-氟-2,3-二氢-3-甲基-10-（4-甲基-1-哌嗪基）-7-氧代-7H-吡啶并[1,2,3 - de][1,4]苯并恶嗪-6-羧酸）显示出比吡哌酸、诺氟沙星、四环素和林可霉素更广泛的抗菌谱和更强的抗支原体活性，但比红霉素弱。其对肺炎支原体临床分离株的杀支原体效力也高于其他喹诺酮类药物和四环素。
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