Abbott R D, Garrison R J, Wilson P W, Epstein F H, Castelli W P, Feinleib M, LaRue C
Arteriosclerosis. 1983 May-Jun;3(3):260-72. doi: 10.1161/01.atv.3.3.260.
During the period 1971 to 1975, the cholesterol content of lipoprotein density classes were measured in 2415 male and female Framingham Heart Study participants and 4342 of their offspring and offspring spouses who were free of coronary heart disease. In this first of three papers, the univariate and bivariate distributions of high density lipoprotein cholesterol, low density lipoprotein cholesterol, and very low density lipoprotein cholesterol are presented. There are differences in the levels of lipoprotein cholesterols by age, gender, and use of hormone preparations. The bivariate cross-tabulations of the three pairs of lipoprotein cholesterol measurements exhibit properties that cannot be appreciated from univariate summary statistics and suggest the importance of joint consideration of different lipoprotein cholesterol patterns for assessing the risk of coronary heart disease.
在1971年至1975年期间，对2415名弗雷明汉心脏研究的男性和女性参与者以及他们4342名无冠心病的后代和后代配偶的脂蛋白密度类别的胆固醇含量进行了测量。在这三篇系列论文的第一篇中，呈现了高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和极低密度脂蛋白胆固醇的单变量和双变量分布情况。脂蛋白胆固醇水平在年龄、性别以及激素制剂使用方面存在差异。三对脂蛋白胆固醇测量值的双变量交叉表呈现出单变量汇总统计中无法察觉的特性，并表明在评估冠心病风险时联合考虑不同脂蛋白胆固醇模式的重要性。
