Fizet D, Bousquet J
Br J Obstet Gynaecol. 1983 May;90(5):453-6. doi: 10.1111/j.1471-0528.1983.tb08943.x.
The serum of pregnant women contains a non-specific immunosuppressive factor able to block an in vitro cellular cytotoxicity reaction. This activity increases during the first trimester and persists for 3 months after delivery. The factor is active in dilution. Ten women who had recurrent abortions were typed for HLA antigens and were found to share several antigens with their husband. In all these women, the 'blocking factor' was absent from their serum. The absence of the 'blocking factor' could be used as a clinical test to predict spontaneous abortion.
孕妇血清中含有一种非特异性免疫抑制因子，能够阻断体外细胞毒性反应。这种活性在妊娠头三个月增加，并在分娩后持续3个月。该因子在稀释时仍具有活性。对10名习惯性流产妇女进行了HLA抗原分型，发现她们与丈夫有几种相同的抗原。在所有这些妇女的血清中，均未发现“阻断因子”。“阻断因子”的缺失可作为预测自然流产的一项临床检测指标。
