McIntyre J A, Faulk W P
Am J Reprod Immunol (1980). 1983 Dec;4(4):165-70. doi: 10.1111/j.1600-0897.1983.tb00272.x.
We have confirmed that many women who suffer from recurrent spontaneous abortions have an increased incidence of histocompatibility (HLA-A, HLA-B, HLA-C, and HLA-DR) antigen-sharing with their husbands. We also found abortion-prone women who did not share HLA with their mates; however, they failed to respond or responded suboptimally to their husbands when compared to third-party controls in the mixed lymphocyte culture (MLC) reactions. Some aborting patients manifested a husband-specific MLC blocking factor in their plasma which was not present in their serum. In contrast, nonpregnant childbearing wives did not share as many of their husbands' HLA antigens as frequently, had normal or heightened MLC responses to their husbands, and showed no evidence of humoral blocking factors. We propose that HLA typing, MLC reactions, and blocking factor studies will serve as useful laboratory indices in future clinical studies of immunogenetical disorders associated with idiopathic habitual abortion.
我们已经证实，许多患有复发性自然流产的女性与其丈夫的组织相容性（HLA - A、HLA - B、HLA - C和HLA - DR）抗原共享发生率增加。我们还发现一些易流产的女性与其配偶不存在HLA共享；然而，与混合淋巴细胞培养（MLC）反应中的第三方对照相比，她们对丈夫的反应不佳或无反应。一些流产患者的血浆中表现出丈夫特异性的MLC阻断因子，而血清中不存在该因子。相比之下，未怀孕的育龄妻子与其丈夫共享的HLA抗原不如前者频繁，对丈夫的MLC反应正常或增强，且未显示出体液阻断因子的证据。我们提出，HLA分型、MLC反应和阻断因子研究将作为未来与特发性习惯性流产相关的免疫遗传学疾病临床研究中的有用实验室指标。
