次黄嘌呤与麦卡德尔病：工作中前臂代谢应激的线索

Hypoxanthine and Mcardle disease: a clue to metabolic stress in the working forearm.

作者信息

Brooke M H, Patterson V H, Kaiser K K

出版信息

Muscle Nerve. 1983 Mar-Apr;6(3):204-6. doi: 10.1002/mus.880060307.

Abstract

Forearm exercise in a patient with myophosphorylase deficiency resulted in abnormally high levels of hypoxanthine in the venous blood. The post-exercise hypoxanthine response may reflect ATP depletion in the muscle and provides a useful screening test in muscle diseases with abnormal energy metabolism.

摘要

在一名患有肌磷酸化酶缺乏症的患者中，前臂运动导致静脉血中次黄嘌呤水平异常升高。运动后次黄嘌呤反应可能反映了肌肉中三磷酸腺苷（ATP）的消耗，并为能量代谢异常的肌肉疾病提供了一种有用的筛查测试。