Oudart H, Heitz A, Bnouham M, Malan A, Le Maho Y
Centre d'Ecologie et de Physiologie Energétiques, CNRS, Strasbourg, France.
Br J Cancer. 1993 Nov;68(5):885-9. doi: 10.1038/bjc.1993.450.
Cancer cachexia is among the most dramatic situations of depletion in body energy reserves. To ascertain whether the pattern of body composition alteration during tumour development is influenced by aging as in uncomplicated starvation, we compared the difference of body composition between Yoshida sarcoma bearing rats and young (200 g, 7 weeks) and adult (400 g, 13 weeks) control rats. After the same duration of tumour bearing, mass and composition of tumours were similar in adult and young rats, indicating that they are independent of host age. Food intake decreased to a remarkably similar value in both young and adults. Body water content was elevated in hosts of both ages. The relative deficit of body lipid vs controls was similar for both, the absolute lipid deficit being therefore larger in adult than in young tumour-bearing rats (14.3 +/- 4.4 g vs 6.8 +/- 0.9 g; P < 0.01). In contrast, there was a relatively larger deficit of body protein in young rats. Paradoxically, these rats still maintained a positive nitrogen balance whereas this balance was negative in adult tumour-bearing rats. In conclusion, as previously shown in uncomplicated undernutrition, the anorexia induced by Yoshida sarcoma development is still associated with some protein accretion in young rats whereas cachexia develops in adults.
癌症恶病质是身体能量储备消耗最为严重的情况之一。为了确定肿瘤发展过程中身体成分改变的模式是否如单纯饥饿那样受衰老影响，我们比较了荷吉田肉瘤大鼠与年轻（200克，7周龄）及成年（400克，13周龄）对照大鼠之间身体成分的差异。在相同的荷瘤持续时间后，成年和年轻大鼠的肿瘤质量和成分相似，表明它们与宿主年龄无关。年轻和成年大鼠的食物摄入量均降至非常相似的值。两个年龄组宿主的身体含水量均升高。与对照组相比，两组大鼠身体脂质的相对缺乏相似，因此成年荷瘤大鼠的绝对脂质缺乏量大于年轻荷瘤大鼠（14.3±4.4克对6.8±0.9克；P<0.01）。相反，年轻大鼠身体蛋白质的相对缺乏量更大。矛盾的是，这些年轻大鼠仍保持正氮平衡，而成年荷瘤大鼠的氮平衡为负。总之，如先前在单纯营养不良中所显示的那样，吉田肉瘤发展诱导的厌食在年轻大鼠中仍与一些蛋白质增加相关，而成年大鼠则发展为恶病质。
