Deboer Mark Daniel
Division of Pediatric Endocrinology, University of Virginia.
Expert Opin Drug Discov. 2009 Nov 1;4(11):1145-1155. doi: 10.1517/17460440903300842.
Cachexia is a devastating syndrome of body wasting that worsens quality of life and survival for patients suffering from diseases such as cancer, chronic kidney disease and chronic heart failure. Successful treatments have been elusive in humans, leaving a clear need for the development of new treatment compounds. Animal models of cachexia are able to recapitulate the clinical findings from human disease and have provided a much-needed means of testing the efficacy of prospective therapies. OBJECTIVE: This review focuses on animal models of cachexia caused by cancer, chronic heart failure and chronic kidney disease, including the features of these models, their implementation, and commonly-followed outcome measures. CONCLUSION: Given a dire clinical need for effective treatments of cachexia, animal models will continue a vital role in assessing the efficacy and safety of potential treatments prior to testing in humans. Also important in the future will be the use of animal models to assess the durability of effect from anti-cachexia treatments and their effect on prognosis of the underlying disease states.
恶病质是一种严重的身体消耗综合征，会降低癌症、慢性肾病和慢性心力衰竭等疾病患者的生活质量并缩短其生存期。人类一直难以找到成功的治疗方法，因此迫切需要开发新的治疗化合物。恶病质动物模型能够重现人类疾病的临床症状，为测试前瞻性疗法的疗效提供了急需的手段。目的：本综述聚焦于由癌症、慢性心力衰竭和慢性肾病引起的恶病质动物模型，包括这些模型的特点、构建方法以及常用的结局指标。结论：鉴于临床上迫切需要有效治疗恶病质的方法，动物模型在评估潜在治疗方法在人体试验前的疗效和安全性方面将继续发挥至关重要的作用。未来，利用动物模型评估抗恶病质治疗效果的持久性及其对基础疾病状态预后的影响也将非常重要。
