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盐诱导的寡聚（dC-dG）两种双螺旋形式之间的转变。

Salt-induced transition between two double-helical forms of oligo (dC-dG).

作者信息

Pohl F M

出版信息

Cold Spring Harb Symp Quant Biol. 1983;47 Pt 1:113-7. doi: 10.1101/sqb.1983.047.01.014.

DOI:10.1101/sqb.1983.047.01.014
PMID:6574834
Abstract

The change between a right-handed and a left-handed double-helical structure is certainly an extreme example of the conformational variability of DNA. Studying the energetics and dynamics with defined oligomers provides a convenient way to obtain a quantitative understanding of such processes and can serve as a model for possible regulatory mechanisms in biological systems. Monoclonal antibodies with different specificities to Z-DNA offer a promising technique to search for such structures in more-complicated systems and represent a model system for the quantitative investigation of the interaction of proteins with particular conformations of DNA.

摘要

右手螺旋结构与左手螺旋结构之间的转变无疑是DNA构象变异性的一个极端例子。利用特定的寡聚物研究能量学和动力学，为定量理解此类过程提供了一种便捷的方法，并且可以作为生物系统中可能的调控机制的模型。对Z-DNA具有不同特异性的单克隆抗体，为在更复杂的系统中寻找此类结构提供了一种很有前景的技术，并且代表了用于定量研究蛋白质与特定DNA构象相互作用的模型系统。

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