The persisting capability for vasodilatation in duct-occluded canine pancreatic segments.

The effect of duct-obliteration and duct-obliteration induced fibrosis on the capability for vasodilatation of the pancreatic vasculature was investigated in dogs. It was demonstrated that the increase of basal blood flow through left pancreatic segments, induced by intra-arterial injection of papaverin, remained unchanged during 6 months after duct-obliteration. It is concluded that impairment of endocrine function of duct-obliterated segmental pancreatic grafts cannot be readily explained by a functional impairment of the pancreatic vessels.