Aufdemorte T B, De Villez R L, Gieseker D R
Oral Surg Oral Med Oral Pathol. 1983 May;55(5):459-62. doi: 10.1016/0030-4220(83)90231-1.
We report three cases of erosive oral lichen planus treated with griseofulvin, 500 mg. twice a day. Subjective improvement was noticed in 3 weeks by two patients and at 6 weeks by the third patient. Objective improvement, however, was delayed and became apparent at 6 to 10 weeks. Continued improvement or remission without exacerbation was noted in all patients. There were no significant hematologic, hepatic, or other side effects in any patient, and complete blood count and blood chemistries remained normal at 1-month as well as 6-month intervals during therapy. All patients did, however, report mild, transient gastrointestinal discomfort during the first 2 days of therapy, and one patient mentioned a mild headache. These remitted after approximately 2 to 4 days. We believe that these preliminary findings warrant additional trials of griseofulvin therapy in the treatment of severely symptomatic oral lichen planus. The adverse effects of this agent appear considerably less than those of systemic steroids.
我们报告了3例糜烂性口腔扁平苔藓患者，用灰黄霉素治疗，每日2次，每次500毫克。2例患者在3周时出现主观症状改善，第3例患者在6周时出现主观症状改善。然而，客观改善出现延迟，在6至10周时才明显。所有患者均持续改善或缓解，无病情加重。所有患者均未出现明显的血液学、肝脏或其他副作用，治疗期间，全血细胞计数和血液化学指标在1个月及6个月时均保持正常。不过，所有患者均报告在治疗的头2天有轻度、短暂的胃肠道不适，1例患者提及有轻度头痛。这些症状在约2至4天后缓解。我们认为，这些初步研究结果表明有必要进一步试验灰黄霉素治疗重度症状性口腔扁平苔藓。该药物的不良反应似乎明显少于全身用类固醇。
