Won Tai Hyok, Park Se Young, Kim Bo Suk, Seo Phil Seung, Park Seok Don
Department of Dermatology, Wonkwang University School of Medicine, Iksan, Korea.
Ann Dermatol. 2009 Aug;21(3):250-4. doi: 10.5021/ad.2009.21.3.250. Epub 2009 Aug 31.
Several different kinds of drugs have been used to treat chronic oral lichen planus (OLP). During the last decade, there have been several reports demonstrating success with levamisole and low dose prednisolone therapy for treating OLP. However, some OLP patients who have underlying diseases such as diabetes, hypertension and malignancy are unable to take steroids.
The aim of this study was to evaluate levamisole monotherapy for treating OLP.
Eleven patients who had OLP were treated with levamisole between 2005 and 2007. The levamisole was administered at a dose 50 mg thrice daily for three consecutive days, but then it was not administered on the following four days.
After 2 weeks of treatment, 8 patients reported a partial response, 3 patients reported no response and no patients reported clearance of lesion. After 4 weeks of treatment, 6 patients reported a partial response, 3 patients reported no response and 2 patients reported clearance of lesion. Furthermore, after 3 months of treatment, 3 patients reported a partial response, 3 patients reported no response and 5 patients reported complete clearance of lesion. Clinical improvement was shown in 2 weeks, whilst the mean duration to achieve clearance of lesion was 6.2 weeks. Although 1 patient had mild itching, there were no significant adverse effects.
Levamisole monotherapy could be a successful and safe treatment option for patients with chronic OLP and who cannot take steroids.
几种不同类型的药物已被用于治疗慢性口腔扁平苔藓（OLP）。在过去十年中，有几份报告表明左旋咪唑和低剂量泼尼松龙治疗OLP取得了成功。然而，一些患有糖尿病、高血压和恶性肿瘤等基础疾病的OLP患者无法服用类固醇。
本研究的目的是评估左旋咪唑单药治疗OLP的效果。
2005年至2007年期间，11例OLP患者接受了左旋咪唑治疗。左旋咪唑的给药剂量为每日三次，每次50毫克，连续服用三天，随后四天不服用。
治疗2周后，8例患者报告有部分缓解，3例患者报告无反应，无患者报告病损清除。治疗4周后，6例患者报告有部分缓解，3例患者报告无反应，2例患者报告病损清除。此外，治疗3个月后，3例患者报告有部分缓解，3例患者报告无反应，5例患者报告病损完全清除。2周时显示出临床改善，而达到病损清除的平均时间为6.2周。虽然1例患者有轻度瘙痒，但无明显不良反应。
对于患有慢性OLP且不能服用类固醇的患者，左旋咪唑单药治疗可能是一种成功且安全的治疗选择。
