Silverman S, Gorsky M, Lozada-Nur F, Giannotti K
School of Dentistry, University of California, San Francisco 94143.
Oral Surg Oral Med Oral Pathol. 1991 Dec;72(6):665-70. doi: 10.1016/0030-4220(91)90007-y.
The findings in this prospective study of 214 patients with oral lichen planus were similar to those found in our 1985 evaluation of 570 patients with oral lichen planus. These two groups of patients with oral lichen planus patients constitute the largest series from one clinic. Oral lichen planus was found mainly in women and most commonly on the buccal mucosa. Spontaneous remissions were infrequent (6.5%), as were malignant transformations (2.3%) in a mean follow-up of 7.5 years. The erosive form of oral lichen planus was most common and was almost always associated with pain. Reproducibly successful management of this T-lymphocyte disease was obtained by selective use of systemic and/or topical corticosteroids. Oral lichen planus was not associated with any evident systemic disease, drug, smoking, or genetic predisposition. Although statistically Candida albicans does not appear to occur disproportionately in large samples of patients with oral lichen planus, in some of the Candida-positive patients, antifungal medications appeared to be useful.
这项针对214例口腔扁平苔藓患者的前瞻性研究结果，与我们1985年对570例口腔扁平苔藓患者的评估结果相似。这两组口腔扁平苔藓患者构成了来自同一诊所的最大样本系列。口腔扁平苔藓主要见于女性，最常见于颊黏膜。在平均7.5年的随访中，自发缓解很少见（6.5%），恶变也很少见（2.3%）。糜烂型口腔扁平苔藓最为常见，几乎总是伴有疼痛。通过选择性使用全身和/或局部皮质类固醇，可重复性地成功治疗这种T淋巴细胞疾病。口腔扁平苔藓与任何明显的全身性疾病、药物、吸烟或遗传易感性均无关联。虽然从统计学上看，白色念珠菌在大量口腔扁平苔藓患者样本中似乎没有不成比例地出现，但在一些念珠菌阳性患者中，抗真菌药物似乎是有用的。
