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大鼠模型中新型纳米氧化锌丁香酚封闭剂对皮下结缔组织的反应

Subcutaneous Connective Tissue Reaction to a New Nano Zinc-Oxide Eugenol Sealer in Rat Model.

作者信息

Omidi Salma, Javidi Maryam, Zarei Mina, Mushakhian Siavash, Jafarian Amirhossein

机构信息

Department of Endodontics, Dental School, Mazandaran University of Medical Sciences, Sari, Iran.

Dental Material Research Center, Department of Endodontics, Dental School, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

Iran Endod J. 2017 Winter;12(1):64-69. doi: 10.22037/iej.2017.13.

Abstract

INTRODUCTION

The aim of this animal study was to evaluate the histological response of the new nano zinc-oxide eugenol (NZOE) sealer in comparison with Pulp Canal Sealer (ZOE based) and AH-26 (epoxy resin sealer).

METHODS AND MATERIALS

A total of 27 Wistar rats were used. Four polyethylene tubes were implanted in the back of each rat (three tubes containing the test materials and an empty tube as a control). Then, 9 animals were sacrificed at each interval of 15, 30 and 60 days, and the implants were removed with the surrounding tissues.Samples were evaluated for the presence of inflammatory cell (mononuclear cell), vascular changes, fibrous tissue formation and present of giant cell. Comparisons between groups and time-periods were performed using the Kruskal-Wallis and Mann-Whitney U non-parametric tests. The level of significance was set at 0.05.

RESULTS

No significant difference was observed in tissue reactions and biocompatibility pattern of three sealers during 3 experimental periods (<0.05). In all groups the tissue behavior showed tendency to decrease the irritation effect over time. The new nano zinc-oxide eugenol sealer has histocompatibility properties comparable to conventional commercial sealers.

摘要

引言

本动物研究的目的是评估新型纳米氧化锌丁香酚(NZOE)封闭剂与牙髓根管封闭剂(基于丁香酚)和AH-26(环氧树脂封闭剂)相比的组织学反应。

方法和材料

总共使用了27只Wistar大鼠。在每只大鼠背部植入四根聚乙烯管(三根管子装有测试材料,一根空管作为对照)。然后,在15、30和60天的每个时间间隔处死9只动物,并将植入物与周围组织一起取出。对样本进行炎症细胞(单核细胞)、血管变化、纤维组织形成和巨细胞存在情况的评估。使用Kruskal-Wallis和Mann-Whitney U非参数检验对组间和时间段进行比较。显著性水平设定为0.05。

结果

在3个实验期内,三种封闭剂的组织反应和生物相容性模式未观察到显著差异(<0.05)。在所有组中,组织行为显示随着时间推移刺激作用有降低的趋势。新型纳米氧化锌丁香酚封闭剂具有与传统市售封闭剂相当的组织相容性特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7a2/5282382/9deb9cf71ba3/iej-12-064-g001.jpg

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