Tatsuta M, Yamamura H, Ichii M, Taniguchi H
J Natl Cancer Inst. 1983 Aug;71(2):361-4.
The effect of histamine on induction of tumors in the forestomach and the glandular stomach after N-nitroso-N-methylnitroguanidine (MNNG) administration was studied in male inbred W rats. Animals were given 50 micrograms MNNG solution/ml orally for 25 weeks and then 4 mg histamine dihydrochloride sc per day in depot form. Administration of histamine in depot form after MNNG significantly increased the incidence of tumors in the forestomach, but it significantly decreased the incidence of adenocarcinomas in the glandular stomach. All of the tumors induced in the forestomach were of the squamous cell type, and 50% of them were squamous cell carcinomas. Histamine alone had no apparent carcinogenicity in rats.
在雄性近交W大鼠中研究了组胺对给予N-亚硝基-N-甲基亚硝基胍（MNNG）后前胃和腺胃肿瘤诱导的影响。动物口服50微克MNNG溶液/毫升，持续25周，然后每天皮下注射4毫克盐酸组胺长效制剂。MNNG给药后给予长效组胺制剂显著增加了前胃肿瘤的发生率，但显著降低了腺胃腺癌的发生率。在前胃诱导的所有肿瘤均为鳞状细胞类型，其中50%为鳞状细胞癌。单独给予组胺在大鼠中没有明显的致癌性。
