Cerar A, Pokorn D
Department for Gastrointestinal Pathology, Institute of Pathology, Ljubljana, Slovenia.
Nutr Cancer. 1996;26(3):347-52. doi: 10.1080/01635589609514490.
There are divergent opinions on the effect of ethanol in the carcinogenesis of gastroduodenal tumors. The effect of the synchronous application of 11% ethanol or wine (11% ethanol) and N-methyl-N'-nitro-N-nitrosoguanidine (100 micrograms/ml, MNNG) in a drinking solution on the incidence of gastroduodenal tumors was evaluated. Sixty outbred male Wistar rats were distributed among three groups. The animals drank MNNG and ethanol or wine for six months and consumed the same quantity of MNNG. Then they consumed a normal diet until the 13th month, when the experiment was terminated. The stomach and duodenum were examined histologically. In the stomach, 15 tumors (2 squamous paillomas, 4 squamous carcinomas, 1 sarcoma, and 8 adenocarcinomas) and 4 cases of dysplasia were found; in the duodenum, there were four cases of adenocarcinoma. There were 6 cases of multiple tumors. Incidence of forestomach tumors did not differ among the groups, whereas the incidence of glandular stomach carcinoma and duodenal carcinoma was significantly lower in the groups treated with 11% ethanol or wine than in the control group. MNNG was not inactivated by ethanol in the drinking solutions. We concluded that the inhibitory effect on gastroduodenal carcinogenesis is the result of 11% ethanol ingestion and its protective action on the mucosa and not of the wine's nonethanol components.
关于乙醇在胃十二指肠肿瘤致癌过程中的作用存在不同观点。评估了在饮用溶液中同时给予11%乙醇或葡萄酒（11%乙醇）与N-甲基-N'-硝基-N-亚硝基胍（100微克/毫升，MNNG）对胃十二指肠肿瘤发生率的影响。60只远交系雄性Wistar大鼠被分为三组。动物饮用MNNG和乙醇或葡萄酒六个月，且摄入相同量的MNNG。然后它们食用正常饮食直至第13个月实验结束。对胃和十二指肠进行组织学检查。在胃中，发现15个肿瘤（2个鳞状乳头状瘤、4个鳞状细胞癌、1个肉瘤和8个腺癌）以及4例发育异常；在十二指肠中，有4例腺癌。有6例多原发肿瘤。前胃肿瘤的发生率在各组间无差异，而11%乙醇或葡萄酒处理组的腺胃癌和十二指肠癌发生率显著低于对照组。饮用溶液中的乙醇并未使MNNG失活。我们得出结论，对胃十二指肠致癌作用的抑制效果是摄入11%乙醇及其对黏膜的保护作用的结果，而非葡萄酒中的非乙醇成分所致。
