Koh S D, Wolpert E A
Psychiatry Res. 1983 Apr;8(4):289-97. doi: 10.1016/0165-1781(83)90017-3.
Previous studies have consistently demonstrated unimpaired memory scanning and retrieval in schizophrenic patients. Using the choice-reaction time paradigm, this study assessed the speed of short-term memory processing for pictorial information in both unipolar and bipolar depressives by comparing it with that of schizophrenics. It was found that the processing rate is comparable between depressives and schizophrenics, between unipolar and bipolar depressives, and between depressives on medication and those not on medication. It was concluded, therefore, that the short-term memory scanning and retrieval processes are not impaired in depressive patients. The results further suggested that the depressives' slowness often found in simple reaction time tasks may result from a dysfunction in their stimulus encoding and/or response execution rather than in the central information-identification process.
先前的研究一直表明，精神分裂症患者的记忆扫描和检索功能未受损。本研究采用选择反应时范式，通过与精神分裂症患者进行比较，评估了单相和双相抑郁症患者对图片信息的短期记忆处理速度。研究发现，抑郁症患者与精神分裂症患者之间、单相和双相抑郁症患者之间以及服用药物和未服用药物的抑郁症患者之间的处理速度相当。因此得出结论，抑郁症患者的短期记忆扫描和检索过程未受损。结果还进一步表明，抑郁症患者在简单反应时任务中经常出现的反应迟缓可能是由于其刺激编码和/或反应执行功能障碍，而非中央信息识别过程的功能障碍所致。
