Raskin D J, Sullivan K H, Rappaport N H
Ann N Y Acad Sci. 1983;411:105-9. doi: 10.1111/j.1749-6632.1983.tb47291.x.
The results of this study indicated that there were no statistically significant differences between the effectiveness of 1% silver sulfadiazine in DMSO and 1% silver sulfadiazine in a hydrophilic base (Silvadene), when these formulations were used as antimicrobials applied topically to thermal burn wounds. The antimicrobial efficacy of silver sulfadiazine was not destroyed by mixing this agent with DMSO, since the recovery of Pseudomonas aeruginosa was significantly lower in all animals treated with silver sulfadiazine, whatever the formulation, when compared to animals not treated with silver sulfadiazine. Further studies with higher concentrations of silver sulfadiazine in DMSO may be useful. Although the concept of DMSO as a medicinal "carrier" is not novel, with further investigation, it may prove to be germane in the treatment of eschar-covered thermal burns.
本研究结果表明，当将1%磺胺嘧啶银的二甲基亚砜制剂和1%磺胺嘧啶银的亲水性基质制剂（磺胺嘧啶银乳膏）用作热烧伤创面的局部抗菌剂时，二者的有效性在统计学上无显著差异。磺胺嘧啶银与二甲基亚砜混合后，其抗菌效力并未被破坏，因为与未用磺胺嘧啶银治疗的动物相比，无论使用何种制剂，用磺胺嘧啶银治疗的所有动物中铜绿假单胞菌的回收率均显著降低。进一步研究更高浓度的二甲基亚砜磺胺嘧啶银制剂可能会有帮助。虽然二甲基亚砜作为药物“载体”的概念并不新颖，但通过进一步研究，它可能在焦痂覆盖的热烧伤治疗中被证明是相关的。
