Miller L, Hansbrough J, Slater H, Goldfarb I W, Kealey P, Saffle J, Kravitz M, Silverstein P
UCSD Medical Center 92103.
J Burn Care Rehabil. 1990 Jan-Feb;11(1):35-41. doi: 10.1097/00004630-199001000-00008.
Wound care is painful for the patient with a burn injury and tedious for the burn unit staff but necessary to remove exudates and debris and to limit infections. In an effort to circumvent daily dressing changes while ensuring optimal wound protection, Sildimac (Marion Laboratories, Kansas City, Mo.), a new drug delivery system for silver sulfadiazine, was developed. When silver sulfadiazine, a topical antimicrobial commonly used for the treatment of burns, is incorporated into the delivery system, the drug is released in a sustained fashion. We report here the results of a multicenter evaluation of the safety and efficiency of Sildimac for treatment of full-thickness burn wounds. Sildimac, when left in place for up to 4 days, appears to be as effective as twice-daily wound cleansing and application of Silvadene cream 1% (Marion Laboratories, Kansas City, Mo.) for the treatment of full-thickness burns.
伤口护理对于烧伤患者来说很痛苦，对于烧伤病房的工作人员来说很繁琐，但对于清除渗出物和碎屑以及控制感染却是必要的。为了在确保最佳伤口保护的同时避免每日换药，开发了一种新的磺胺嘧啶银给药系统Sildimac（马里恩实验室，密苏里州堪萨斯城）。当将常用于治疗烧伤的局部抗菌药物磺胺嘧啶银纳入该给药系统时，药物会持续释放。我们在此报告对Sildimac治疗全层烧伤伤口的安全性和有效性进行多中心评估的结果。Sildimac在原位放置长达4天时，对于治疗全层烧伤似乎与每日两次伤口清洁并涂抹1%的磺胺嘧啶银乳膏（马里恩实验室，密苏里州堪萨斯城）一样有效。
