Chaganti R S, Jhanwar S C, Arlin Z, Koziner B, Ambati A, Andreeff M, Clarkson B D
Cancer Genet Cytogenet. 1983 Sep;10(1):95-103. doi: 10.1016/0165-4608(83)90110-3.
A patient with L3 leukemia is reported whose leukemic cells were characterized cytogenetically by a duplication of the long arm segment 1q25 leads to q42, trisomy for chromosome 7, t(8;22)(q24;q11), and two 14q+ chromosomes. Immunologic marker analysis revealed the leukemic cells to be of the non-T, non-B ("null") type. This observation, when considered in conjunction with a previous report of heterogeneity in cell lineages of L3 leukemias, raises the possibility of some lymphoid neoplasms arising in stem cells.
