Roth D G, Cimino M C, Variakojis D, Golomb H M, Rowley J D
Blood. 1979 Feb;53(2):235-43.
An adult patient with acute lymphoblastic leukemia associated with a 14q+ marker chromosome is presented. The abnormality resulted from a translocation of material from the long arm of chromosome 11. The leukemic cells were found to be B cells on the basis of surface immunoglobulins, lack of receptors for sheep erythrocytes, and a characteristically low level of adenosine deaminase activity. In other patients with ALL studied by us or reported by others in whom chromosome banding was done, a 14q+ chromosome was present in only one instance, also a case of B cell ALL. These two cases are the only examples of B cell ALL studied with chromosome banding reported to date. The frequent occurrence of a 14q+ chromosome in other malignant lymphoproliferative diseases of B cell origin suggests that a general association may exist between the 14q+ abnormality and B cell neoplasms. Cytogenetic analysis may therefore be useful in defining subtypes of ALL and in relating specific chromosomal abnormalities to lymphoproliferative disorders.
本文报告了一名患有急性淋巴细胞白血病并伴有14q +标记染色体的成年患者。该异常是由于11号染色体长臂的物质易位所致。根据表面免疫球蛋白、缺乏绵羊红细胞受体以及腺苷脱氨酶活性水平显著降低，发现白血病细胞为B细胞。在我们研究或其他人报告的其他进行了染色体显带分析的急性淋巴细胞白血病患者中，仅在一例患者中发现了14q +染色体，该患者也是B细胞急性淋巴细胞白血病病例。这两个病例是迄今为止报道的仅有的两例进行了染色体显带分析的B细胞急性淋巴细胞白血病。在其他B细胞起源的恶性淋巴增殖性疾病中频繁出现14q +染色体，提示14q +异常与B细胞肿瘤之间可能存在普遍关联。因此，细胞遗传学分析可能有助于定义急性淋巴细胞白血病的亚型，并将特定的染色体异常与淋巴增殖性疾病相关联。
