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Coexistence of cells with unmasked and masked Ph1 in a case of chronic myeloid leukemia in blastic phase.

作者信息

Pedersen B

出版信息

Cancer Genet Cytogenet. 1984 Jun;12(2):129-37. doi: 10.1016/0165-4608(84)90124-9.

DOI:10.1016/0165-4608(84)90124-9
PMID:6586280
Abstract

Bone marrow from a patient with chronic myeloid leukemia in blastic phase at diagnosis showed cells with t(9;22), as well as others with a 22q+ marker. The marker was due to t(8;22), and consequently, these cells presented a masked Ph1: t(8;9;22) (q24.2;q34;q11). The marrow contained a wide variety of abnormal clones, which formed an evolutionary pedigree. The pedigree allowed location of the stage of evolution at which masking of the Ph1 had taken place.

摘要

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