Minguell J J, Martínez J
Exp Hematol. 1983 Jul;11(6):522-6.
Studies were conducted on cultures of adherent cells derived from bone marrow of normal (N-BMF) and ALL (ALL-BMF) children. Quiescent cultures of both types of cells are differentially stimulated to synthesize DNA by serum. A 31-fold increase was observed in N-BMF, while in ALL-BMF, serum stimulates DNA synthesis only up to 7 times. Hydrocortisone (10(-8) M) inhibited up to 50% the effect of serum on DNA synthesis in N-BMF and had no effect in ALL-BMF. Glucocorticoid receptors, already described in N-BMF, are either absent or present in low amounts in ALL-BMF. These results indicate that stromal cells from normal and ALL bone marrow differ both in growth pattern and function.
对源自正常儿童（N-BMF）和急性淋巴细胞白血病儿童（ALL-BMF）骨髓的贴壁细胞培养物进行了研究。两种类型细胞的静止培养物受血清刺激后会差异合成DNA。在N-BMF中观察到DNA合成增加了31倍，而在ALL-BMF中，血清仅能刺激DNA合成增加7倍。氢化可的松（10(-8) M）可抑制血清对N-BMF中DNA合成的作用达50%，而对ALL-BMF无作用。N-BMF中已描述有糖皮质激素受体，而ALL-BMF中要么不存在该受体，要么含量很低。这些结果表明，正常骨髓和急性淋巴细胞白血病骨髓的基质细胞在生长模式和功能上均存在差异。
