Matharu S S, Ramsden C H, Kester R C
Curr Med Res Opin. 1978;5(6):427-32. doi: 10.1185/03007997809111910.
The levels of cephradine were measured in serum, voluntary muscle and subcutaneous fat samples collected from 30 patients during surgical operations for peripheral vascular disease. Cephradine 2 g was administered in two equal doses by intramuscular and intravenous routes before each operation. The mean levels found in the serum and muscle were well above the minimum inhibitory concentrations required for most important Gram-positive and Gram-negative pathogens, in contrast to the relatively low mean level found in subcutaneous fat.
在30例接受外周血管疾病手术的患者术中采集血清、随意肌和皮下脂肪样本，测定其中头孢拉定的含量。每次手术前通过肌肉注射和静脉注射两种途径等量给予2g头孢拉定。血清和肌肉中的平均含量远高于大多数重要革兰氏阳性和革兰氏阴性病原体所需的最低抑菌浓度，相比之下，皮下脂肪中的平均含量相对较低。
