大麻对苯巴比妥诱导酶的影响。
Effect of cannabis on enzyme induction by phenobarbital.
作者信息
Sanz P, Villar P, Repetto M
出版信息
Arch Toxicol Suppl. 1983;6:115-20. doi: 10.1007/978-3-642-69083-9_17.
Cannabis extracts in olive oil administered s.c. to male adult rats decreases oxidizing microsomal enzymes measured as TPNH disappearance and AHH activity in liver postmitochondrial fraction (93.06% and 25.54% maximum inhibition respectively in chronic treatments). Simultaneous administration of single doses of cannabis extracts (330 mg/kg s.c.) and phenobarbital (100 mg/kg i.p.) causes impairment of total microsomal oxidases (86.83% inhibition) and decreases AHH (31.86% inhibition), thus blocking the enzyme induction by phenobarbital.
将大麻提取物溶于橄榄油中，皮下注射给成年雄性大鼠，可降低肝线粒体后组分中以TPNH消失量和AHH活性衡量的氧化微粒体酶活性（慢性处理时最大抑制率分别为93.06%和25.54%）。同时给予单剂量的大麻提取物（330毫克/千克，皮下注射）和苯巴比妥（100毫克/千克，腹腔注射）会损害总微粒体氧化酶（抑制率为86.83%）并降低AHH活性（抑制率为31.86%），从而阻断苯巴比妥的酶诱导作用。
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