CXB重组近交系小鼠对Friend辅助病毒白血病的易感性。
Susceptibility to Friend helper virus leukemias in CXB recombinant inbred mice.
作者信息
Silver J E, Fredrickson T N
出版信息
J Exp Med. 1983 Nov 1;158(5):1693-702. doi: 10.1084/jem.158.5.1693.
Abstract
The seven CXB recombinant inbred strains were tested for susceptibility to Friend helper virus (F-MuLV) hematopoietic neoplasms. BALB/c and CXB-H mice develop erythroblastosis after neonatal inoculation with F-MuLV, while C57BL/6 and the six other RI strains develop lymphoma and myelogenous leukemia. This strain distribution pattern is different from that for H-2, Gpd-1 (linked to Fv-1), Fv-2, Rfv-3, and Cv (linked to Rmcf) but the same as that for Bv, the endogenous ecotropic virus of C57BL/6. However, analysis of crosses segregating Bv show that resistance to F-MuLV erythroblastosis is not linked to Bv. Disease-free survival is shortest for BALB/c mice, intermediate for CXB-H and CXB-J, and longest for C57BL/6 and the other RI strains. We conclude: (a) the major C57BL/6 gene for resistance to F-MuLV erythroblastosis is different from previously identified Friend virus restriction loci; (b) latency for F-MuLV leukemias is controlled by more than one gene; and (c) latency and susceptibility to F-MuLV erythroblastosis are not inherited concordantly in the CXB-RI strains.
摘要
对七种CXB重组近交系小鼠进行了对Friend辅助病毒（F-MuLV）造血肿瘤易感性的测试。BALB/c和CXB-H小鼠在新生期接种F-MuLV后会发生成红细胞增多症，而C57BL/6和其他六种重组近交系小鼠会发生淋巴瘤和髓性白血病。这种品系分布模式与H-2、Gpd-1（与Fv-1连锁）、Fv-2、Rfv-3和Cv（与Rmcf连锁）不同，但与C57BL/6的内源性嗜亲性病毒Bv相同。然而，对分离Bv的杂交后代的分析表明，对F-MuLV成红细胞增多症的抗性与Bv不连锁。无病生存期对BALB/c小鼠最短，对CXB-H和CXB-J为中等，对C57BL/6和其他重组近交系小鼠最长。我们得出以下结论：（a）C57BL/6中对F-MuLV成红细胞增多症抗性的主要基因与先前确定的Friend病毒限制位点不同；（b）F-MuLV白血病的潜伏期受多个基因控制；（c）在CXB重组近交系中，F-MuLV成红细胞增多症的潜伏期和易感性并非一致遗传。
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