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一种对红细胞具有特异性的转录增强子位于弗氏小鼠白血病病毒的长末端重复序列中。

A transcriptional enhancer with specificity for erythroid cells is located in the long terminal repeat of the Friend murine leukemia virus.

作者信息

Bösze Z, Thiesen H J, Charnay P

出版信息

EMBO J. 1986 Jul;5(7):1615-23. doi: 10.1002/j.1460-2075.1986.tb04404.x.

DOI:10.1002/j.1460-2075.1986.tb04404.x
PMID:3462001
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1166987/
Abstract

We investigated the ability of the U3 region of the long terminal repeats (LTR) of the Friend murine leukemia virus (Fr-MuLV) and Moloney murine leukemia virus (Mo-MuLV) to promote transcription in a variety of human cell lines. Our analysis reveals the presence of a transcriptional enhancer with specificity for erythroid cells in the U3 region of the Fr-MuLV. This constitutes the first example of an enhancer with such a property. Analysis of the Mo-MuLV enhancer suggests that it is active at least in erythroid and lymphoid cells and has thus a less restricted specificity than the Fr-MuLV enhancer. The different tissue specificities of the two enhancers correlate with the different tissue selectivities and pathogenic properties of the two viruses.

摘要

我们研究了弗氏小鼠白血病病毒（Fr-MuLV）和莫洛尼小鼠白血病病毒（Mo-MuLV）长末端重复序列（LTR）的U3区域在多种人类细胞系中促进转录的能力。我们的分析揭示，在Fr-MuLV的U3区域存在一种对红系细胞具有特异性的转录增强子。这是具有这种特性的增强子的首个实例。对Mo-MuLV增强子的分析表明，它至少在红系和淋巴系细胞中具有活性，因此与Fr-MuLV增强子相比，其特异性限制较少。两种增强子不同的组织特异性与两种病毒不同的组织选择性和致病特性相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685e/1166987/b70373357e62/emboj00170-0207-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685e/1166987/3b2e4dbfe4d4/emboj00170-0203-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685e/1166987/522b79dc2622/emboj00170-0204-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685e/1166987/108fe182bc89/emboj00170-0206-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685e/1166987/b70373357e62/emboj00170-0207-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685e/1166987/3b2e4dbfe4d4/emboj00170-0203-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685e/1166987/522b79dc2622/emboj00170-0204-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685e/1166987/108fe182bc89/emboj00170-0206-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685e/1166987/b70373357e62/emboj00170-0207-a.jpg

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A transcriptional enhancer with specificity for erythroid cells is located in the long terminal repeat of the Friend murine leukemia virus.一种对红细胞具有特异性的转录增强子位于弗氏小鼠白血病病毒的长末端重复序列中。
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Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells.转染至淋巴细胞中的免疫球蛋白重链基因的表达与调控
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A single-base change at a splice site in a beta 0-thalassemic gene causes abnormal RNA splicing.β0地中海贫血基因剪接位点的单碱基变化导致异常的RNA剪接。
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Isolation of transplantable erythroleukemia cells from mice infected with helper-independent Friend murine leukemia virus.
鉴定负责Friend白血病病毒变体FIS-2快速免疫抑制活性和低致白血病潜力的遗传决定因素。
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Spi-1/PU.1 transgenic mice develop multistep erythroleukemias.Spi-1/PU.1转基因小鼠会发生多步骤的红白血病。
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Protection against retroviral diseases after vaccination is conferred by interference to superinfection with attenuated murine leukemia viruses.接种疫苗后对逆转录病毒疾病的保护作用是通过干扰减毒鼠白血病病毒的重复感染来实现的。
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Sequences responsible for the distinctive hemolytic potentials of Friend and Moloney murine leukemia viruses are dispersed but confined to the psi-gag-PR region.负责弗瑞德和莫洛尼小鼠白血病病毒独特溶血潜能的序列是分散的，但局限于ψ- gag - PR区域。
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Negative regulation of the 5' long terminal repeat (LTR) by the 3' LTR in the murine proviral genome.鼠前病毒基因组中3'长末端重复序列对5'长末端重复序列的负调控。
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Function of a unique sequence motif in the long terminal repeat of feline leukemia virus isolated from an unusual set of naturally occurring tumors.从一组不寻常的自然发生肿瘤中分离出的猫白血病病毒长末端重复序列中独特序列基序的功能。
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从感染无辅助型弗氏小鼠白血病病毒的小鼠中分离可移植性红白血病细胞。
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Characterization of enhancer elements in the long terminal repeat of Moloney murine sarcoma virus.莫洛尼鼠肉瘤病毒长末端重复序列中增强子元件的特性分析。
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Cell-specific expression controlled by the 5'-flanking region of insulin and chymotrypsin genes.由胰岛素基因和胰凝乳蛋白酶基因的5'侧翼区域控制的细胞特异性表达。
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