位于5号染色体上的一个小鼠基因，它限制水貂细胞灶形成重组鼠白血病病毒的感染性。
A mouse gene on chromosome 5 that restricts infectivity of mink cell focus-forming recombinant murine leukemia viruses.
作者信息
Hartley J W, Yetter R A, Morse H C
出版信息
J Exp Med. 1983 Jul 1;158(1):16-24. doi: 10.1084/jem.158.1.16.
Abstract
DBA/1, DBA/2, CBA/N, and CBA/Ca mice carry a gene which specifically restricts infectivity of mink cell focus-forming (MCF) murine leukemia viruses. The gene, designated Rmcfr, is dominant or semidominant and maps to chromosome 5; it is closely linked to the morphologic marker gene Hm. The Rmcf gene may be of much use as a means of determining the role of MCF viruses in various forms of leukemogenesis.
摘要
DBA/1、DBA/2、CBA/N和CBA/Ca小鼠携带一种基因，该基因能特异性限制貂细胞集落形成（MCF）鼠白血病病毒的感染性。该基因命名为Rmcfr，呈显性或半显性，定位于5号染色体；它与形态学标记基因Hm紧密连锁。Rmcf基因作为一种确定MCF病毒在各种白血病发生形式中作用的手段可能非常有用。
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本文引用的文献
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Suppression of spontaneous lymphoma by previously undiscovered dominant genes in crosses of high- and low-incidence mouse strains.在高发病率和低发病率小鼠品系杂交中，先前未发现的显性基因对自发性淋巴瘤的抑制作用。
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Normal DBA/2 mouse cells synthesize a glycoprotein which interferes with MCF virus infection.正常的DBA/2小鼠细胞合成一种糖蛋白，这种糖蛋白会干扰MCF病毒的感染。
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Cloning of endogenous murine leukemia virus-related sequences from chromosomal DNA of BALB/c and AKR/J mice: identification of an env progenitor of AKR-247 mink cell focus-forming proviral DNA.从BALB/c和AKR/J小鼠染色体DNA中克隆内源性鼠白血病病毒相关序列：鉴定AKR-247貂细胞集落形成前病毒DNA的env前体。
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Friend murine leukemia virus-induced leukemia is associated with the formation of mink cell focus-inducing viruses and is blocked in mice expressing endogenous mink cell focus-inducing xenotropic viral envelope genes.Friend小鼠白血病病毒诱导的白血病与貂细胞集落诱导病毒的形成有关，并且在表达内源性貂细胞集落诱导异种嗜性病毒包膜基因的小鼠中受到阻断。
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