Seymour G J, Powell R N, Aitken J F
J Periodontol. 1983 Sep;54(9):522-8. doi: 10.1902/jop.1983.54.9.522.
AN EXPERIMENTAL GINGIVITIS STUDY was carried out to relate the clinical parameters (plaque and gingival index) to the histologic appearance of the associated gingival lesions. Fifteen third-year dental students took part in the study. Following the withdrawal of oral hygiene, biopsies were taken on days 0, 4, 8 and 21 of the experimental period. A statistically significant association was found between the plaque and gingival indices and the various time intervals throughout the experimental period (P less than 0.001). At day 0, although all sites had a GI of 0, all but 2 of the 15 specimens showed some degree of inflammation. Histologically, these lesions consisted of over 60% lymphocytes, while plasma cells comprised less than 5% of the infiltrating population. Although the degree of inflammation increased both clinically and histologically throughout the experimental period, the nature of the infiltrate did not change significantly. Lymphocytes remained as the dominant cell type. In fact, no association was seen between the degree of inflammation and the nature of the infiltrating cells.
开展了一项实验性牙龈炎研究，以将临床参数（菌斑和牙龈指数）与相关牙龈病变的组织学表现联系起来。15名三年级牙科学生参与了该研究。在停止口腔卫生措施后，于实验期的第0、4、8和21天进行活检。在整个实验期内，菌斑和牙龈指数与各个时间间隔之间存在统计学上的显著关联（P小于0.001）。在第0天，尽管所有部位的牙龈指数均为0，但15个标本中除2个外，其余均显示出一定程度的炎症。组织学上，这些病变由超过60%的淋巴细胞组成，而浆细胞占浸润细胞群的比例不到5%。尽管在整个实验期内炎症程度在临床和组织学上均有所增加，但浸润的性质没有显著变化。淋巴细胞仍然是主要的细胞类型。事实上，炎症程度与浸润细胞的性质之间没有关联。
