慢性牙周炎患者牙周基础治疗前后龈沟液中白细胞介素-4和干扰素-γ的变化
Changes in gingival crevicular fluid interleukin-4 and interferon-gamma in patients with chronic periodontitis before and after periodontal initial therapy.
作者信息
Tsai Chi-Cheng, Ku Chia-Hsin, Ho Ya-Ping, Ho Kun-Yen, Wu Yi-Min, Hung Chun-Cheng
机构信息
Graduate Institute of Dental Sciences, College of Dental Medicine, Kaohsiung Medical University, and Department of Periodontics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
出版信息
Kaohsiung J Med Sci. 2007 Jan;23(1):1-7. doi: 10.1016/S1607-551X(09)70367-5.
Abstract
Cytokines are pivotal to the immune response of chronic periodontitis. The present study investigated the changes of gingival crevicular fluid (GCF) interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in patients with chronic periodontitis before and after initial nonsurgical periodontal therapy (NSPT). GCF was collected from 17 patients by means of Periopaper at baseline and 1 month after NSPT. IL-4 and IFN-gamma were measured by enzyme-linked immunoabsorbent assay. NSPT resulted in decreased total amount of IFN-gamma, increased concentration of IL-4, and increased ratio of IL-4 to IFN-gamma levels. We suggest that a low ratio of IL-4 to IFN-gamma levels might be involved in the destruction (diseased sites) of periodontal tissue, whereas an increased ratio of IL-4 to IFN-gamma levels could be related to the improvement of clinical periodontal health.
摘要
细胞因子对慢性牙周炎的免疫反应至关重要。本研究调查了慢性牙周炎患者在初始非手术牙周治疗（NSPT）前后龈沟液（GCF）中白细胞介素-4（IL-4）和干扰素-γ（IFN-γ）的变化。通过Periopaper从17名患者的基线和NSPT后1个月收集GCF。采用酶联免疫吸附测定法测量IL-4和IFN-γ。NSPT导致IFN-γ总量减少、IL-4浓度增加以及IL-4与IFN-γ水平的比值增加。我们认为，IL-4与IFN-γ水平的低比值可能与牙周组织的破坏（患病部位）有关，而IL-4与IFN-γ水平比值的增加可能与临床牙周健康的改善有关。
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本文引用的文献
1
[Changes of circulating IFN-gamma, IL-4 in patients with chronic periodontitis before and after periodontal initial therapy].
Shanghai Kou Qiang Yi Xue. 2005 Apr;14(2):131-3.
2
PERIODONTAL DISEASE IN PREGNANCY. II. CORRELATION BETWEEN ORAL HYGIENE AND PERIODONTAL CONDTION.妊娠期牙周病。II. 口腔卫生与牙周状况的相关性
Acta Odontol Scand. 1964 Feb;22:121-35. doi: 10.3109/00016356408993968.
3
Effect of inflammation, smoking and stress on gingival crevicular fluid cytokine level.炎症、吸烟和压力对龈沟液细胞因子水平的影响。
J Clin Periodontol. 2003 Feb;30(2):145-53. doi: 10.1034/j.1600-051x.2003.300201.x.
4
Immunohistological study of interferon-gamma- and interleukin-4-bearing cells in human periodontitis gingiva.人牙周炎牙龈中携带γ-干扰素和白细胞介素-4细胞的免疫组织学研究
Arch Oral Biol. 2001 Oct;46(10):901-8. doi: 10.1016/s0003-9969(01)00057-7.
5
Anti-inflammatory cytokine IL-10 and T cell cytokine profile in periodontitis granulation tissue.牙周炎肉芽组织中的抗炎细胞因子白细胞介素-10及T细胞细胞因子谱
Clin Exp Immunol. 2001 Feb;123(2):294-300. doi: 10.1046/j.1365-2249.2001.01448.x.
6
Cytokine profiles of T-lymphocytes from gingival tissues with pathological pocketing.来自伴有病理性牙周袋的牙龈组织的T淋巴细胞的细胞因子谱。
J Dent Res. 2000 Aug;79(8):1548-55. doi: 10.1177/00220345000790080401.
7
Th1 and Th2 cytokine profile in patients with early onset periodontitis and their healthy siblings.早发性牙周炎患者及其健康同胞的Th1和Th2细胞因子谱
Mediators Inflamm. 2000;9(2):115-20. doi: 10.1080/096293500411587.
8
Interferon-gamma and interleukin 4 inhibit interleukin 1beta-induced delayed prostaglandin E(2)generation through suppression of cyclooxygenase-2 expression in human fibroblasts.干扰素-γ和白细胞介素4通过抑制人成纤维细胞中环氧合酶-2的表达来抑制白细胞介素1β诱导的前列腺素E2的延迟生成。
Cytokine. 2000 Jun;12(6):603-12. doi: 10.1006/cyto.1999.0622.
9
Intracellular interleukin-1 alpha production in human gingival fibroblasts is differentially regulated by various cytokines.人牙龈成纤维细胞内白细胞介素-1α的产生受多种细胞因子的差异调节。
J Dent Res. 1999 Apr;78(4):840-9. doi: 10.1177/00220345990780040401.
10
Early-onset and adult periodontitis associated with abnormal cytokine production by activated T lymphocytes.早发性和成人牙周炎与活化T淋巴细胞产生异常细胞因子有关。
J Periodontol. 1998 Oct;69(10):1098-104. doi: 10.1902/jop.1998.69.10.1098.
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