Changes in gingival crevicular fluid interleukin-4 and interferon-gamma in patients with chronic periodontitis before and after periodontal initial therapy.
作者信息
Tsai Chi-Cheng, Ku Chia-Hsin, Ho Ya-Ping, Ho Kun-Yen, Wu Yi-Min, Hung Chun-Cheng
机构信息
Graduate Institute of Dental Sciences, College of Dental Medicine, Kaohsiung Medical University, and Department of Periodontics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
出版信息
Kaohsiung J Med Sci. 2007 Jan;23(1):1-7. doi: 10.1016/S1607-551X(09)70367-5.
Abstract
Cytokines are pivotal to the immune response of chronic periodontitis. The present study investigated the changes of gingival crevicular fluid (GCF) interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in patients with chronic periodontitis before and after initial nonsurgical periodontal therapy (NSPT). GCF was collected from 17 patients by means of Periopaper at baseline and 1 month after NSPT. IL-4 and IFN-gamma were measured by enzyme-linked immunoabsorbent assay. NSPT resulted in decreased total amount of IFN-gamma, increased concentration of IL-4, and increased ratio of IL-4 to IFN-gamma levels. We suggest that a low ratio of IL-4 to IFN-gamma levels might be involved in the destruction (diseased sites) of periodontal tissue, whereas an increased ratio of IL-4 to IFN-gamma levels could be related to the improvement of clinical periodontal health.
摘要
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