Tsai Chi-Cheng, Ku Chia-Hsin, Ho Ya-Ping, Ho Kun-Yen, Wu Yi-Min, Hung Chun-Cheng
Graduate Institute of Dental Sciences, College of Dental Medicine, Kaohsiung Medical University, and Department of Periodontics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Kaohsiung J Med Sci. 2007 Jan;23(1):1-7. doi: 10.1016/S1607-551X(09)70367-5.
Cytokines are pivotal to the immune response of chronic periodontitis. The present study investigated the changes of gingival crevicular fluid (GCF) interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in patients with chronic periodontitis before and after initial nonsurgical periodontal therapy (NSPT). GCF was collected from 17 patients by means of Periopaper at baseline and 1 month after NSPT. IL-4 and IFN-gamma were measured by enzyme-linked immunoabsorbent assay. NSPT resulted in decreased total amount of IFN-gamma, increased concentration of IL-4, and increased ratio of IL-4 to IFN-gamma levels. We suggest that a low ratio of IL-4 to IFN-gamma levels might be involved in the destruction (diseased sites) of periodontal tissue, whereas an increased ratio of IL-4 to IFN-gamma levels could be related to the improvement of clinical periodontal health.
细胞因子对慢性牙周炎的免疫反应至关重要。本研究调查了慢性牙周炎患者在初始非手术牙周治疗（NSPT）前后龈沟液（GCF）中白细胞介素-4（IL-4）和干扰素-γ（IFN-γ）的变化。通过Periopaper从17名患者的基线和NSPT后1个月收集GCF。采用酶联免疫吸附测定法测量IL-4和IFN-γ。NSPT导致IFN-γ总量减少、IL-4浓度增加以及IL-4与IFN-γ水平的比值增加。我们认为，IL-4与IFN-γ水平的低比值可能与牙周组织的破坏（患病部位）有关，而IL-4与IFN-γ水平比值的增加可能与临床牙周健康的改善有关。
