Utsui Y, Ohya S, Takenouchi Y, Tajima M, Sugawara S, Deguchi K, Suginaka H
J Antibiot (Tokyo). 1983 Oct;36(10):1380-6. doi: 10.7164/antibiotics.36.1380.
The effect of cefmetazole on the growth together with the release of cellular lipoteichoic acid from cefazolin-resistant strains of Staphylococcus aureus was compared with that of cefazolin, cefotiam, cefoxitin and cefuroxime. Bacteriolytic actions were measured by turbidity and bactericidal actions were followed by viable cell count. Release of cellular lipoteichoic acid was measured by the radioactivity in the supernatant of the cultures. Cefmetazole exerted more potent effects on the bacterial growth and induced more marked release of cellular lipoteichoic acid from resistant strains as compared with other beta-lactams.
将头孢美唑与头孢唑林、头孢替安、头孢西丁和头孢呋辛相比，研究其对耐头孢唑林金黄色葡萄球菌生长及细胞脂磷壁酸释放的影响。通过浊度测量溶菌作用，通过活菌计数跟踪杀菌作用。通过培养上清液中的放射性测量细胞脂磷壁酸的释放。与其他β-内酰胺类药物相比，头孢美唑对细菌生长的作用更强，且能诱导耐药菌株释放更显著的细胞脂磷壁酸。
