Reznik-Schüller H M, Gregg M
J Natl Cancer Inst. 1983 Nov;71(5):1021-31.
The pathogenesis of hepatocellular tumors induced in F344 rats by the antihistaminic methapyrilene was investigated by light and electron microscopy in a serial sacrifice study. Eosinophilic foci of altered hepatocytes were found in portal areas after 1 week of treatment, the eosinophilia being caused by proliferation of mitochondria. Eosinophilic neoplastic nodules developed from such lesions after 16 weeks of treatment. Hepatocellular carcinomas developed after 26 weeks of treatment. Mitochondrial proliferation, which had been found as a marker for hepatocytes altered by this compound at 1 week of treatment, was still present in the hepatocellular carcinomas, which therefore met the morphologic criteria of oncocytomas.
在一项连续处死研究中，通过光学显微镜和电子显微镜对抗组胺药甲氧芐二胺诱导F344大鼠肝细胞肿瘤的发病机制进行了研究。治疗1周后，在门管区发现嗜酸性的肝细胞改变灶，嗜酸性是由线粒体增殖引起的。治疗16周后，此类病变发展为嗜酸性肿瘤结节。治疗26周后出现肝细胞癌。线粒体增殖在治疗1周时被发现是受该化合物影响的肝细胞的标志物，在肝细胞癌中仍然存在，因此符合嗜酸细胞瘤的形态学标准。
