Pritchard D J, Butler W H
British Industrial Biological Research Association, Carshalton, Surrey, UK.
Br J Exp Pathol. 1988 Dec;69(6):793-804.
Hepatocellular carcinoma was induced in rats by administering aflatoxin B1 (AFB1) for 6 weeks. Malignant tumours were preceded by foci and nodules of altered hepatocytes. The ultrastructural characteristics of the nodular lesions have been studied and compared with those of the hepatocellular carcinoma cells. Alterations in the endoplasmic reticulum, junctional complexes and nuclei were common to both the basophilic and eosinophilic nodular cells and the carcinoma cells. These most likely represent hyperplastic changes rather than malignant alterations. The eosinophilic nodules were distinguished from other lesions by the abundance of concentric, membranous whorls in the cytoplasm of nodular cells. These cytoplasmic structures were also present in some hepatocellular carcinoma cells. The observations provided further evidence suggesting that the eosinophilic nodule, rather than the basophilic nodule, may play a role in the development of malignancy in the rat liver.
通过给予黄曲霉毒素B1（AFB1）6周诱导大鼠发生肝细胞癌。恶性肿瘤之前存在肝细胞改变的灶和结节。已对结节性病变的超微结构特征进行了研究，并与肝细胞癌细胞的特征进行了比较。嗜碱性和嗜酸性结节细胞及癌细胞的内质网、连接复合体和细胞核均有改变。这些很可能代表增生性变化而非恶性改变。嗜酸性结节与其他病变的区别在于结节细胞胞质中存在大量同心膜性漩涡。这些胞质结构也存在于一些肝细胞癌细胞中。这些观察结果提供了进一步的证据，表明嗜酸性结节而非嗜碱性结节可能在大鼠肝脏恶性肿瘤的发生中起作用。
