Ross M H, Lustbader E D, Bras G
J Natl Cancer Inst. 1983 Nov;71(5):1041-6.
The mature body weight of outbred CD-Crl:COBS CD(SD)BR male rats permitted to select their own diets throughout life was shown to correlate linearly with the frequency of spontaneous tumors. In an analysis of the dietary practices of these animals, a multifactorial model was derived--for which prepuberty and early post-puberty data only were used--that accounted for a large proportion of the variance in mature weight. The level of food or calorie intake proved less informative than the following: the interactive effects of food intake relative to body weight, the proportion of protein and carbohydrate constituents in the diet, the intake of each of these components, and, particularly, the efficiency with which the diet consumed was used for growth during early postweaning life. In a prospective study of other rats maintained on a similar feeding regimen, the model was found to be an accurate predictor of mature weight. Several of the explanatory factors necessary for estimation of body weight also contributed to tumor susceptibility. Nonetheless, both dietary and body weight-related factors in a specific time-related sequence were required to explain variation in spontaneous tumor susceptibility.
研究表明，终生可自行选择饮食的远交群CD-Crl:COBS CD(SD)BR雄性大鼠的成熟体重与自发性肿瘤的发生频率呈线性相关。在对这些动物饮食习惯的分析中，得出了一个多因素模型——该模型仅使用了青春期前和青春期后早期的数据——该模型解释了成熟体重差异的很大一部分。事实证明，食物或卡路里摄入量的信息不如以下因素丰富：食物摄入量相对于体重的交互作用、饮食中蛋白质和碳水化合物成分的比例、这些成分各自的摄入量，尤其是断奶后早期饮食消耗用于生长的效率。在对其他采用类似喂养方案的大鼠进行的前瞻性研究中，发现该模型是成熟体重的准确预测指标。估计体重所需的几个解释性因素也与肿瘤易感性有关。尽管如此，仍需要特定时间相关序列中的饮食和体重相关因素来解释自发性肿瘤易感性的差异。
