Lundberg C, Engquist S
Scand J Infect Dis Suppl. 1983;39:53-5.
Some recent studies concerning the pathogenesis of the maxillary sinusitis is surveyed. The importance of normal sinus ventilation for maintenance of a healthy sinus is stressed. It is concluded that granulocytes in the sinus secretion play an important role in the defence of the mucosa against potentially invading bacteria, but that the granulocytes in purulent secretions release proteases in high concentrations causing heavy inflammatory response in the mucosa. It is also concluded that although bacteria only rarely and not invariably invade the mucosa, bacteria in the secretion activate the humoral and cellular defence systems. When the stimuli are strong, the release of granulocyte protease in tissues and secretion can surpass the capacity of the locally available protease inhibitors and tissue destruction will ensue.
本文综述了近期一些关于上颌窦炎发病机制的研究。强调了正常鼻窦通气对维持健康鼻窦的重要性。得出的结论是，鼻窦分泌物中的粒细胞在黏膜抵御潜在入侵细菌的防御中起重要作用，但脓性分泌物中的粒细胞会高浓度释放蛋白酶，从而在黏膜中引发强烈的炎症反应。还得出结论，尽管细菌很少且并非总是侵入黏膜，但分泌物中的细菌会激活体液和细胞防御系统。当刺激强烈时，组织和分泌物中粒细胞蛋白酶的释放可能超过局部可用蛋白酶抑制剂的能力，进而导致组织破坏。
