Stark A, Aparisi T, Ericsson J L
Ultrastruct Pathol. 1983 Jun;4(4):311-29. doi: 10.3109/01913128309140584.
The fine structure of representative regions of 13 osteoblastic osteogenic sarcomas was studied. These regions contained four morphologically distinguishable subtypes of osteoblastlike cells. In addition, fibroblastlike and chondroblastlike cells were present, along with multinucleated giant cells, leukocytes, macrophagelike cells, and small populations of histogenetically unclassifiable (but probably neoplastic) cells. The morphologic evidence was compatible with the view that the variations in appearance among the subgroups of osteoblastlike cells reflected differences in maturation and differentiation of these cells. In at least one subgroup, the morphologic findings suggested that the cells were capable of manufacturing a secretory product. The multinucleated giant cells occurring in genuine tumor areas appeared to be closely related to neoplastic osteoblasts. The presence of chondroblastlike cells in the tissues illustrates that cells with a diverging differentiation can occur in an osteoblast-dominated cell population. This agrees with the view that the neoplastic cells originate from a mesenchymal stem cell with potential for multifaceted differentiation.
对13例成骨细胞性骨肉瘤代表性区域的精细结构进行了研究。这些区域包含四种形态上可区分的成骨细胞样细胞亚型。此外，还存在成纤维细胞样和软骨母细胞样细胞，以及多核巨细胞、白细胞、巨噬细胞样细胞和少量组织发生学上无法分类（但可能是肿瘤性）的细胞。形态学证据与以下观点相符，即成骨细胞样细胞亚群之间外观的差异反映了这些细胞成熟和分化的差异。在至少一个亚群中，形态学发现表明这些细胞能够产生分泌产物。真正肿瘤区域出现的多核巨细胞似乎与肿瘤性成骨细胞密切相关。组织中软骨母细胞样细胞的存在说明在以成骨细胞为主的细胞群体中可以出现具有不同分化的细胞。这与肿瘤细胞起源于具有多向分化潜能的间充质干细胞的观点一致。
