Stark A, Aparisi T, Ericsson J L
Ultrastruct Pathol. 1984;6(1):51-67. doi: 10.3109/01913128409016665.
The fine structure of representative regions of four chondroblastic osteogenic sarcomas was studied. These regions contained four morphologically distinguishable subtypes of chondroblastlike cells. In addition, multinucleated giant cells, fibroblastlike cells, and macrophagelike cells were present, along with small populations of unclassifiable cells forming at least two subgroups of cells likely to be of a neoplastic nature. With only one exception, all types of chondroblastlike cells were separated by wide zones of extracellular matrix. The large multinucleated cells showed a fine structure that differed from that seen in multinucleated giant cells of other tissues. The evidence suggested that the multinucleated cells in the chondroblastic osteogenic sarcomas were active in phagocytic functions. It is not clear whether or not they are neoplastic in nature. Osteoblastlike cells were not encountered in the chondroid areas of the osteogenic sarcomas studied. On the basis of the findings it is concluded that the observed fine structural polymorphism of the chondroblastlike cells may reflect differences in maturation and differentiation among these cells. The most well-differentiated cells (type 1) appear to be able to exert secretory functions.
对4例软骨母细胞性骨肉瘤代表性区域的精细结构进行了研究。这些区域包含4种形态上可区分的软骨母细胞样细胞亚型。此外，还存在多核巨细胞、成纤维细胞样细胞和巨噬细胞样细胞，以及少量难以分类的细胞，这些细胞至少形成了两个可能具有肿瘤性质的细胞亚群。除1例外，所有类型的软骨母细胞样细胞均被宽阔的细胞外基质区域分隔。大的多核细胞呈现出与其他组织中的多核巨细胞不同的精细结构。有证据表明，软骨母细胞性骨肉瘤中的多核细胞具有活跃的吞噬功能。尚不清楚它们在本质上是否为肿瘤性的。在所研究的骨肉瘤的软骨样区域未发现成骨细胞样细胞。根据这些发现得出结论，观察到的软骨母细胞样细胞精细结构的多态性可能反映了这些细胞在成熟和分化方面的差异。分化最完全的细胞（1型）似乎能够发挥分泌功能。
