Stark A, Aparisi T, Ericsson J L
Ultrastruct Pathol. 1984;7(4):301-19. doi: 10.3109/01913128409141491.
The fine structure of representative regions of nine fibroblastic osteogenic sarcomas was studied. As judged by light microscopic criteria, the tumors represented both highly malignant (grades 3-4) and less malignant (grade 2) varieties. By electron microscopy, six basic cell types were found in the selected regions (fibroblastlike, histiocytelike, and myofibroblastlike cells, along with xanthoma cells, multinucleated giant cells, and undifferentiated cells). In addition, occasional osteoblastlike cells were encountered. Fibroblastlike cells in general, and especially in grade 2 tumors, showed a fine structure, enabling differentiation from osteoblastlike cells. Multinucleated giant cells were of two morphologic types, and the fine structure appeared to be related to the malignancy potential and differentiation of the tumors. Many multinucleated giant cells in grade 2 tumors had a ruffled border and appeared to be highly active in digestive events (especially phagocytosis of whole cells and portions of cells). Accumulation of variable amounts of lipid in droplet form was common in the various types of cells present in the tissues. The observations were discussed with particular emphasis on the interrelationships and functional roles of the cells.
对9例成纤维细胞性骨肉瘤的代表性区域的精细结构进行了研究。根据光学显微镜标准判断，这些肿瘤包括高度恶性（3 - 4级）和低度恶性（2级）的类型。通过电子显微镜观察，在所选择的区域发现了六种基本细胞类型（成纤维细胞样、组织细胞样和肌成纤维细胞样细胞，以及黄色瘤细胞、多核巨细胞和未分化细胞）。此外，偶尔还会遇到成骨细胞样细胞。一般来说，成纤维细胞样细胞，尤其是2级肿瘤中的成纤维细胞样细胞，具有能够与成骨细胞样细胞相区分的精细结构。多核巨细胞有两种形态类型，其精细结构似乎与肿瘤的恶性潜能和分化有关。2级肿瘤中的许多多核巨细胞有褶皱缘，并且在消化活动（特别是对整个细胞和细胞部分的吞噬作用）中似乎高度活跃。组织中存在的各种类型细胞中普遍可见以液滴形式积累的不同量脂质。对这些观察结果进行了讨论，特别强调了细胞之间的相互关系和功能作用。
