前列腺素E2对大鼠1α,25-二羟基维生素D3合成的刺激作用。

Stimulatory effect of prostaglandin E2 on 1 alpha,25-dihydroxyvitamin D3 synthesis in rats.

作者信息

Yamada M, Matsumoto T, Takahashi N, Suda T, Ogata E

出版信息

Biochem J. 1983 Oct 15;216(1):237-40. doi: 10.1042/bj2160237.

DOI:10.1042/bj2160237

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1152492/

Abstract

The effect of prostaglandin E2 on accumulation in plasma of 1 alpha,25-dihydroxy[3H]vitamin D3 from 25-hydroxy[3H]vitamin D3 was studied in vivo using vitamin D-deficient thyroparathyroidectomized rats. Intra-arterial infusion of 10-50 micrograms of prostaglandin E2/h caused a significant stimulation of 1 alpha,25-dihydroxy[3H]vitamin D3 production. No significant changes in plasma Ca2+ and Pi concentrations or urinary cyclic AMP excretion were observed after prostaglandin E2 infusion. Theophylline did not enhance the effect of a submaximal dose of prostaglandin E2 on 1 alpha,25-dihydroxy[3H]vitamin D3 production. These data indicate that prostaglandin E2 stimulates plasma accumulation of 1 alpha,25-dihydroxy[3H]vitamin D3 independent of the adenylate cyclase/cyclic AMP system, and suggest that prostaglandin E2 has a modulatory role in the regulation of 25-hydroxyvitamin D3 1 alpha-hydroxylase in the kidney.

摘要

利用维生素D缺乏的甲状腺甲状旁腺切除大鼠，在体内研究了前列腺素E2对25-羟基[3H]维生素D3在血浆中积累1α,25-二羟基[3H]维生素D3的影响。以每小时10 - 50微克的剂量动脉内输注前列腺素E2可显著刺激1α,25-二羟基[3H]维生素D3的产生。输注前列腺素E2后，血浆Ca2+和Pi浓度或尿中环磷酸腺苷排泄未观察到显著变化。茶碱不会增强次最大剂量的前列腺素E2对1α,25-二羟基[3H]维生素D3产生的作用。这些数据表明，前列腺素E2独立于腺苷酸环化酶/环磷酸腺苷系统刺激血浆中1α,25-二羟基[3H]维生素D3的积累，并提示前列腺素E2在肾脏中对25-羟基维生素D3 1α-羟化酶的调节中具有调节作用。

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